Gasconade County is located in east-central Missouri, and is part of the St. Louis Metropolitan Statistical Area. The county seat is Hermann. The county was organized in 1820 and named after the Gasconade River.

The government of Gasconade County, Missouri is composed of a three-member County Commission, elected from three districts, and a County Clerk, elected at-large. The County Commission is responsible for setting the budget, levying taxes, and making policy decisions. The County Clerk is responsible for maintaining records, issuing licenses, and conducting elections.

The county is home to several state parks, including the Gasconade River State Park and the Meramec State Park. The county is also home to several wineries, including the Stone Hill Winery and the Hermannhof Winery.

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